- Title
- Reduction of prothrombin and Factor V levels following supplementation with omega-3 fatty acids is sex dependent: a randomised controlled study
- Creator
- Phang, Melinda; Scorgie, Fiona E.; Seldon, Michael; Garg, Manohar L.; Lincz, Lisa F.
- Relation
- Journal of Nutritional Biochemistry Vol. 25, Issue 10, p. 997-1002
- Publisher Link
- http://dx.doi.org/10.1016/j.jnutbio.2014.05.001
- Publisher
- Elsevier
- Resource Type
- journal article
- Date
- 2014
- Description
- Background: LCn-3PUFA comprised of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) offer cardioprotection involving a decrease in coagulant activity; however, the evidence is equivocal. We have previously demonstrated that the acute (24. h) effects and chronic (4. weeks) effects of LCn-3PUFA supplementation on platelet aggregation in human subjects are sex specific. This study investigated the mechanisms of the sex-dependent effects of LCn-3PUFA with 4. weeks supplementation of EPA-rich vs. DHA-rich oils on procoagulant and platelet activity in healthy subjects. Design: A double-blinded, placebo-controlled randomised trial was conducted in 94 healthy adults: male (n=41) and female (n=53). Platelet coagulation parameters including factors I, II, V, VII, VIII, IX, X, vWF:Ag and endogenous thrombin potential were measured at baseline and 4 weeks post supplementation with EPA-rich or DHA-rich oil capsules. Results: We have previously reported that platelet aggregation is specifically reduced by supplementation with EPA in males and DHA in females. This sex-specific effect was also observed for decreases in plasma levels of Factor II (-7.9±3.8%, P=.026), Factor V (-6.5±4.5%, P=.022) and vWF:Ag (-7.3±2.1%, P=.034) and was most pronounced in males supplemented with EPA. In contrast, DHA-mediated reduction in platelet aggregation in females was not accompanied by any significant changes in the coagulation parameters tested. Conclusion: Significant interactions between sex and specific LCn-3PUFA exist to reduce procoagulant activity differentially in males vs. females and could have profound effects on managing risk of thrombotic disease.
- Subject
- hemostatic markers; procoagulant activity; LCn-3PUFA; sex-dependent; platelets
- Identifier
- http://hdl.handle.net/1959.13/1304806
- Identifier
- uon:20929
- Identifier
- ISSN:0955-2863
- Language
- eng
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